GPAT 360

MONOPHASIC LIQUID DOSAGE FORMS Mono-Single Monophasic – single phase dosage forms Examples: solutions, aromatic waters and tinctures A.   SOLUTIONS Monophasic system of two or more substances, e.g. sodium chloride solution, Pharmaceutical solutions are defined as the liquid preparations containing one or more chemical substances usually dissolved in water. Methods of preparation 1. Simple dissolution: Solute + suitable solvent → with/without heat → solution e.g. Morphine hydrochloride solution, Adrenaline hydrochloride solution. 2. Solution by chemical reaction: Reaction of two or more solutes → in suitable solvent. e.g. Aluminium acetate solution Al 2 (SO 4 ) 3 +3CaCO 3 +4CH 3 COOH → 2Al.(CH 3 COO) 2 .OH +3CaSO 4 +3CO 2 +H 2 O  3.  Solutions by extraction: Removal of active constituents from crude drugs with the help of solvent. e.g. liquid extracts and tinctures. Solutions for internal use: Taken orally: mixtures, elixirs, tinctures, draught

Affinity chromatography Affinity chromatography  is a method of separating biochemical mixture based on a highly specific interaction between antigen and antibody , enzyme and substrate , receptor and ligand , or protein and nucleic acid . Back in the year of post-graduation, I have delivered a seminar on Affinity Chromatography. Its Powerpoint presentation is not so good and I did not include much text in the ppt. Rather I have decided to include only the informative pictures and I explained the whole topic only with those pictures. (I got good grade for this!) So, here is this ppt. You can download it if you want! DOWNLOAD   AFFINITY CHROMTOGRAPHY [PPT] For preparation of this topic I downloaded A Handbook of Affinity Chromatography. The principle and methods of this chromatography are well explained in this book. I am giving link of this book for you.  Don't forget to download and read!  DOWNLOAD HANDBOOK OF AFFINITY CHROMATOGRAPHY [PDF] Do you know the components of affinity m

Chromtography is an interesting section in Pharmaceutical Analysis subject. Here, I have compiled various chromatographic techniques in one/ two documents. INDEX 1. Classification of chromatography 2. Thin layer chromatography (TLC) 3. High Performance Liquid Chromatography (HPLC) 4. Ion Exchange Chromatography  Following pdf also contains various sub-sections with detailed information about chromatographic techniques.  Click on the following link to download pdf. DOWNLOAD  CHROMATOGRAPHY [PDF]