PHARMACEUTICS GPAT SHORT NOTES III

1. Capsule number and their approximate capacity in mg and ml

No. : mg : ml

000 : 950 : 1.37

00 : 650 : 0.95

0 : 450 : 0.68

1 : 300 : 0.50

2 : 250 : 0.37

3 : 200 : 0.30

4 : 150 : 0.21

5 : 100 : 0.13

¶ Remember that 000 is the largest capsule size while 5 is the smallest size.

2. Sucrose based diluents
1. DiPac : 97% sucrose + 3% modified dextrose
2. Nutab : 95% sucrose + 4% invert sugar
3. Sugar tab : 90-93% sucrose + 7-10% invert sugar

3. Proportions (of respective oil) required for a primary emulsion

( Oil: water: gum)

Fixed oils -- 4 : 2 : 1

Mineral oils -- 3 : 2 : 1

Volatile oils -- 2 : 2 : 1

Oleoresins -- 1 : 2 : 1

4. How to remember the names of Span and Tween surfactants?

Tweens are known as Polysorbates or polyoxyethylene sorbitan fatty acids.
Spans are known as Sorbitan esters.
Generally used Tweens and Spans have grades such as 20, 40, 60 and 80.

Remember the code LPSO
L: Laurate : 20
P: Palmitate: 40
S: Stearate : 60
O: Oleate : 80

Examples:
TWEEN 20: Polyoxyethylene sorbitan monolaurate
TWEEN 60: Polyoxyethylene sorbitan monostearate
SPAN 40: Sorbitan mono palmitate
SPAN 80: Sorbitan mono oleate

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